Journal Article

Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy

Hiroshi Ohtani, Hideki Wakui, Atsushi Komatsuda, Shin Okuyama, Rie Masai, Nobuki Maki, Akihiro Kigawa, Ken-ichi Sawada and Hirokazu Imai

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 19, issue 3, pages 574-579
Published in print March 2004 | ISSN: 0931-0509
Published online March 2004 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfg616
Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy

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Background. Several studies have shown a predominant glomerular deposition of IgG4 in patients with idiopathic membranous nephropathy (MN), whereas significant depositions of other IgG subclasses have been shown in patients with lupus-associated MN and bucillamine-induced MN.

Methods. We examined the distribution patterns of glomerular IgG subclass deposits in 10 patients with malignancy-associated MN (M-MN) and in 15 patients with idiopathic MN by immunofluorescence (IF) microscopy.

Results. The glomerular IF intensities of IgG1 and IgG2 were significantly stronger in the malignancy group than in the idiopathic group (P<0.05). In contrast, there were no differences in glomerular IF intensities of IgG3 and IgG4 between the two groups.

Conclusion. Our findings suggest that the distribution patterns of glomerular IgG subclass deposits are different in idiopathic MN and M-MN. The strong IF intensity of glomerular IgG1 and IgG2 in M-MN may provide a possible predictor for this condition.

Keywords: IgG subclasses; immune complex; immunofluorescence; malignancy; membranous nephropathy

Journal Article.  2314 words.  Illustrated.

Subjects: Nephrology

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