Journal Article

No association of G-463A myeloperoxidase gene polymorphism with MPO–ANCA-associated vasculitis

Anette Fiebeler, Stefan Borgmann, Alexander Woywodt, Hermann Haller and Marion Haubitz

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 19, issue 4, pages 969-971
Published in print April 2004 | ISSN: 0931-0509
Published online April 2004 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfh025
No association of G-463A myeloperoxidase gene polymorphism with MPO–ANCA-associated vasculitis

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Background. The activation of neutrophils and monocytes by ANCA, resulting in the release of reactive oxygen species and proteases like myeloperoxidase (MPO), is essential to the pathogenesis of ANCA-associated vasculitis. As the A allele of the G-463A MPO gene polymorphism is associated with diminished activity of MPO, it is conceivable that the presence of this allele protects against MPO–ANCA-associated vasculitis.

Methods. Allelic frequencies of the G-463A polymorphism were studied in 119 ANCA-associated vasculitis patients, 48 with MPO–ANCA and 71 with proteinase 3 (PR3)–ANCA.

Results. Allelic frequencies of MPO G-463A promoter polymorphism did not differ between MPO–ANCA- and PR3–ANCA-associated vasculitis patients. Moreover, allelic distribution was similar to that of the normal population.

Conclusions. The data suggest that G-463A polymorphism does not seem to contribute to either MPO–ANCA- or PR3–ANCA-associated vasculitis formation.

Keywords: ANCA; microscopic polyangiitis; myeloperoxidase; polymorphism; vasculitis; Wegener's granulomatosis

Journal Article.  1594 words. 

Subjects: Nephrology

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