Journal Article

Causes and therapy of microinflammation in renal failure

Ralf Schindler

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 19, issue suppl_5, pages v34-v40
Published in print August 2004 | ISSN: 0931-0509
Published online August 2004 | e-ISSN: 1460-2385 | DOI:
Causes and therapy of microinflammation in renal failure

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Microinflammation in renal failure has been the subject of numerous studies, but the causes of the inflammatory response in these patients are not clear. There are several potential causes and possible therapies for microinflammation, and they are discussed in this review with regard to uraemia and acidosis, heart failure and volume overload, oxidative stress and iron therapy, and bioincompatibility, especially regarding dialysis membranes. In addition, issues regarding dialysate contamination and access site infection are examined, followed by a discussion of possible drug therapy for microinflammation with angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, statins, aspirin, and antioxidants, such as vitamin E.

Keywords: cardiac failure; dialysis; drug therapy; microinflammation; oxidative stress; uraemia

Journal Article.  0 words. 

Subjects: Nephrology

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