Journal Article

Urinary endothelin-1 excretion according to morpho-functional damage lateralization in reflux nephropathy

Catia Olianti, Alessio Imperiale, Marco Materassi, Daniela Seracini, Rita Ienuso, Mariasilvia Tommasi, Alberto Pupi and Giuseppe La Cava

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 19, issue 7, pages 1774-1778
Published in print July 2004 | ISSN: 0931-0509
Published online March 2004 | e-ISSN: 1460-2385 | DOI:
Urinary endothelin-1 excretion according to morpho-functional damage lateralization in reflux nephropathy

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Background. Reflux nephropathy (RN) is a pathophysiological human model of reduced nephron reserve, due to loss of renal mass, but little information exists about the role of urinary endothelin-1 (uET-1) in this disease. The aim of this study was to assess the presence of uET-1-like-immunoreactivity (uET-1L) in RN patients, particularly if lateralized renal damage existed.

Methods. Thirty patients with vescico-ureteral reflux (VUR) and consequent RN, were studied. The presence of VUR was established by voiding cysto-urethrography. RN was assessed and graded by 99mTc-dimercapto-succinic acid scan (DMSA). Renal plasma flow (ERPF) was evaluated by 123I-Hippuran renal sequential scintigraphy, and glomerular filtration rate (GFR) by creatinine clearance. Forty-five healthy subjects were selected as a control group. uET-1L excretion, in both affected and control groups, was assayed.

Results. Mann–Whitney U test showed a significant difference between control and patient groups in both GFR and uET-1L. A good correlation between DMSA grading, single kidney clearance and VUR grade was shown. A significant relationship was also shown between uET-1L and both ERPF and GFR. Patients with RN were divided into two subgroups according to functional damage lateralization. Between the two groups, a significant difference was found only for uET-1L when GFR was applied as a covariate in ANCOVA analysis.

Conclusion. Our preliminary results confirmed the increase of urinary ET-1L excretion in RN, especially when renal functional injury was lateralized.

Keywords: endothelin-1; ERPF; GFR; 123-I-OIH; reflux nephropathy; vescicoureteral reflux

Journal Article.  3159 words. 

Subjects: Nephrology

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