Journal Article

Urinary <span class="smallCaps">l</span>-lactate excretion is increased in renal Fanconi syndrome

Arumugavelu Thirumurugan, Andrew Thewles, Rodney D. Gilbert, Sally-Anne Hulton, David V. Milford, Christopher J. Lote and C. Mark Taylor

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 19, issue 7, pages 1767-1773
Published in print July 2004 | ISSN: 0931-0509
Published online April 2004 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfh213
Urinary l-lactate excretion is increased in renal Fanconi syndrome

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Background. Measurement of l-lactate in body fluids is an established clinical tool to identify disorders of cellular respiration. However, there is very little known about the clinical value of urinary lactate measurements. We investigated urinary lactate excretion in children with renal Fanconi syndrome.

Methods. Freshly voided urine samples were obtained from children with Fanconi syndrome and controls both with and without renal disease. Urine lactate was estimated by conversion to pyruvate in the presence of lactate dehydrogenase and NAD. The NADH produced was measured photometrically. Urine lactate was factored for urine creatinine.

Results. Children with Fanconi syndrome had a significantly higher urine lactate/creatinine ratio [mean: 84 × 10–2 mmol/mmol; 95% confidence interval (CI): 40.8–127.1 × 10–2 mmol/mmol] than healthy controls (mean: 1.3 × 10−2 mmol/mmol; CI: 1.1–1.5 × 10−2 mmol/ mmol) and those with a variety of renal diseases (mean: 3.1 × 10–2 mmol/mmol; CI: 1.8–4.5 × 10–2 mmol/mmol).

Conclusions. Urinary lactate is increased in Fanconi syndrome. The increase is likely to be due to reduced lactate co-transport in the proximal tubule. Urinary lactate/creatinine has clinical utility as a sensitive test of disordered proximal renal tubular function.

Keywords: Fanconi syndrome; lactate co-transport; proximal tubule disorders; urinary lactate cystinosis

Journal Article.  3526 words.  Illustrated.

Subjects: Nephrology

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