Journal Article

Serum levels of macrophage-colony stimulating factor (M-CSF): a marker of kidney allograft rejection

Yannick Le Meur, Valérie Leprivey-Lorgeot, Sandrine Mons, Mattew José, Jacques Dantal, Brigitte Lemauff, Jean-Claude Aldigier, Claude Leroux-Robert and Vincent Praloran

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 19, issue 7, pages 1862-1865
Published in print July 2004 | ISSN: 0931-0509
Published online May 2004 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfh257
Serum levels of macrophage-colony stimulating factor (M-CSF): a marker of kidney allograft rejection

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Background. Macrophage-colony stimulating factor (M-CSF) is the principal factor for survival of monocytes and macrophages that play an important role in allograft rejection. We studied M-CSF serum levels during successful renal transplantation and acute graft rejection.

Methods. A total of 114 kidney allograft recipients were assessed for M-CSF levels by enzyme-linked immunosorbent assay (ELISA).

Results. M-CSF serum levels were elevated in pre-transplant haemodialysis patients (611±355 IU/ml vs 168±61 in normal controls, P<0.01). Following successful renal transplantation, M-CSF decreased in the first month, stabilizing at 257±222 IU/ml (not significantly different from normal controls) in 52 post-transplant stable patients. There was no correlation between M-CSF level and creatinine clearance. M-CSF levels increased significantly (2–5 times) during biopsy-proven acute rejection episodes in 20 of 25 patients. All rejection episodes were successfully treated and serum M-CSF decreased rapidly to pre-rejection levels in 17/20 patients. In contrast, in five patients with cyclosporin toxicity and four patients with other causes of allograft dysfunction, M-CSF serum levels did not change.

Conclusions. M-CSF serum level might be a specific marker of acute rejection. The source of increased production during rejection warrants further investigation, with infiltrating T cells and resident kidney cells being likely candidates.

Keywords: acute rejection; kidney graft; macrophage; macrophage-colony stimulating factor

Journal Article.  2759 words.  Illustrated.

Subjects: Nephrology

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