Journal Article

Important differentiation of factors that predict outcome in peritoneal dialysis patients with different degrees of residual renal function

Angela Yee-Moon Wang, Jean Woo, Mei Wang, Mandy Man-Mei Sea, John E. Sanderson, Siu-Fai Lui and Philip Kam-Tao Li

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 20, issue 2, pages 396-403
Published in print February 2005 | ISSN: 0931-0509
Published online June 2004 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfh331
Important differentiation of factors that predict outcome in peritoneal dialysis patients with different degrees of residual renal function

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Background. Residual renal function (RRF) is an important predictor of outcome in peritoneal dialysis (PD) patients. Whether results from survival studies in dialysis patients with RRF can also be extrapolated to anuric patients remains uncertain. In this observational study, we examined the characteristics of PD patients with a residual glomerular filtration rate (GFR) ≥1 ml/min per 1.73 m2 vs those with complete anuria and differentiated factors that predict outcome in the two groups of patients.

Methods. Two hundred and forty-six continuous ambulatory peritoneal dialysis (CAPD) patients (39% being completely anuric) were recruited from a single regional dialysis centre. Assessments of haemodynamic, echocardiographic, nutritional and biochemical parameters and indices of dialysis adequacy were done at study baseline and were related to outcomes.

Results. During the prospective follow-up of 30.8±13.8 (mean±SD) months, 28.0% of patients with residual GFR ≥1 ml/min per 1.73 m2 vs 50.5% of anuric patients had died (P = 0.005). The overall 2 year patient survival was 89.7 and 65.0% for patients with GFR ≥1 ml/min per 1.73 m2 and anuric patients, respectively (P = 0.0012). Compared with patients with GFR ≥1 ml/min per 1.73 m2, anuric patients were dialysed for longer (P<0.001), were more anaemic (P<0.005), and had higher calcium–phosphorus product (P<0.01), higher C-reactive protein (P<0.001), lower serum albumin (P<0.05), greater prevalence of malnutrition according to subjective global assessment (P<0.05) and more severe cardiac hypertrophy (P<0.001) at baseline. Using multivariable Cox regression analysis, serum albumin, left ventricular mass index and residual GFR were significant factors associated with mortality in patients with GFR ≥1 ml/min per 1.73 m2, while increasing age, atherosclerotic vascular disease and higher C-reactive protein were associated with greater mortality in anuric PD patients.

Conclusions. Our study demonstrates more adverse cardiovascular, inflammatory, nutritional and metabolic profiles as well as higher mortality in anuric PD patients. Furthermore, factors associated with mortality are also not equivalent for PD patients with and without RRF, suggesting that patients with and without RRF are qualitatively different.

Keywords: cardiovascular; inflammation; malnutrition; mortality; peritoneal dialysis

Journal Article.  4402 words.  Illustrated.

Subjects: Nephrology

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