Journal Article

Daily on-line haemodiafiltration: a pilot trial in children

Michel Fischbach, Joëlle Terzic, Vincent Laugel, Céline Dheu, Soraya Menouer, Pauline Helms and Angelo Livolsi

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 19, issue 9, pages 2360-2367
Published in print September 2004 | ISSN: 0931-0509
Published online July 2004 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfh403
Daily on-line haemodiafiltration: a pilot trial in children

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Background. Despite major improvements in paediatric dialysis over the last two decades, cardiovascular outcome is often poor. As France gives priority to kidney transplantation over dialysis, children in chronic haemodialysis are generally pre-adolescents or adolescents with long medical histories and low compliance. In them, the usual weekly schedule of dialysis is often unsuitable. We conducted a study of conversion to daily dialysis, which allowed an enhanced dialysis dose, a gentle ultrafiltration rate and achievement of dry body weight.

Methods. In this single-centre, observational, prospective, non-randomized study, five oligoanuric dialysis patients (mean age: 13.8 ± 3.2 years) were converted from standard on-line haemodiafiltration (S-OL-HDF) (4 h, three times/week) to daily on-line haemodiafiltration (D-OL-HDF) (3 h, six times/week). Patient selection was based on both the presence of uraemic cardiomyopathy (left ventricular hypertrophy and reduced fractional shortening) and their reduced therapeutic compliance. The D-OL-HDF parameters were the same as for the S-OL-HDF.

Results. Increasing the number of sessions from three to six weekly positively impacted the weekly dialysis dose. On D-OL-HDF, mean arterial blood pressure decreased significantly (from 95 ± 15 to 82 ± 13 and 87 ± 9 mmHg at 6 and 12 months, respectively). Left ventricular hypertrophy decreased and its fractional shortening improved markedly (from 26.6 ± 17% to 31 ± 14% and 46.6 ± 15% at 6 and 12 months, respectively). Pre-dialytic plasma phosphorus also decreased markedly (from 1.87 ± 0.23 to 1.43 ± 0.22 and 1.28 ± 0.29 mmol/l at 6 and 12 months, respectively), as did the calcium–phosphorus product. The post-dialytic recovery time disappeared and so did perception of fatigue. Fasting the day before dialysis to avoid excess weight gain (necessitating longer dialysis) disappeared. Combined with an improved appetite, these changes resulted in higher caloric and protein intake (nPCR), from 1.28 ± 0.23 to 1.43 ± 0.24 g/kg at 6 months, and school attendance became regular. The only pre-pubertal child included showed catch-up growth.

Conclusions. Increasing dialysis frequency to daily sessions without shortening the durations of sessions excessively allowed us to overcome the ‘free diet’ imposed on these paediatric, very uncompliant patients. This strategy led to a reduction in blood pressure and an improvement of left ventricular size and function, normalization of pre-dialytic plasma phosphorus and improvements in general well-being and dialysis acceptance. Long-term, however, this protocol is only acceptable for the children if associated with the potential of clinical recovery allowing inscription on the kidney transplantation waiting list.

Keywords: daily haemodialysis; growth rate; nutrition; on-line haemodiafiltration; ventricular function; ventricular hypertrophy

Journal Article.  4394 words.  Illustrated.

Subjects: Nephrology

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