Journal Article

Restless legs syndrome, insomnia and quality of life in patients on maintenance dialysis

Istvan Mucsi, Miklos Zsolt Molnar, Csaba Ambrus, Lilla Szeifert, Agnes Zsofia Kovacs, Rezső Zoller, Szabolcs Barótfi, Adam Remport and Marta Novak

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 20, issue 3, pages 571-577
Published in print March 2005 | ISSN: 0931-0509
Published online January 2005 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfh654
Restless legs syndrome, insomnia and quality of life in patients on maintenance dialysis

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Background. In a cross-sectional study, we analysed the complex relationship between restless legs syndrome (RLS), insomnia and specific insomnia symptoms and health-related quality of life (QoL) in patients on maintenance dialysis.

Methods. Data were obtained from 333 patients on chronic maintenance dialysis. To assess the prevalence of RLS, we used the RLS Questionnaire (RLSQ). The Athens Insomnia Scale (AIS) was used to assess insomnia and QoL was measured with the Kidney Disease Quality-of-Life Questionnaire.

Results. The prevalence of RLS was 14%. The number of comorbid conditions was significantly higher in patients with vs without RLS (median: three vs two; P<0.05). RLS patients were twice as likely to have significant insomnia as patients without RLS (35% vs 16%; P<0.05). Furthermore, RLS was associated with impaired overall sleep quality (median AIS score: 8 vs 4; P<0.01) and poorer QoL. RLS was a significant and independent predictor of several of the QoL domains after statistical adjustment for clinical and socio-demographic covariables. Importantly, this association remained significant even after adjusting for sleep quality.

Conclusions. RLS is associated with poor sleep, increased odds for insomnia and impaired QoL in patients on maintenance dialysis. Based on the present results, we suggest that both sleep-related and sleep-independent factors may confer the effect of RLS on QoL.

Keywords: insomnia; maintenance dialysis; quality of life; restless legs syndrome

Journal Article.  4412 words.  Illustrated.

Subjects: Nephrology

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