Journal Article

Diagnosis and monitoring a case of light-chain deposition disease in the kidney using a new, sensitive immunoassay

Ian Brockhurst, Kevin P. G. Harris and Claire S. Chapman

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 20, issue 6, pages 1251-1253
Published in print June 2005 | ISSN: 0931-0509
Published online March 2005 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfh749
Diagnosis and monitoring a case of light-chain deposition disease in the kidney using a new, sensitive immunoassay

Show Summary Details

Preview

A 59-year-old male was diagnosed with nephrotic syndrome secondary to light-chain deposition disease. There was no other evidence of a B cell clonal disorder or amyloidosis; circulating free light chains were identified using a new immunoassay (Freelite) and used to monitor disease progression. Improvement in renal function and proteinuria following VAMP chemotherapy correlated with a reduction in circulating light-chain levels. This case demonstrates a new tool in monitoring light-chain deposition disease in the kidney.

Keywords: chemotherapy; Freelite assay; light-chain deposition disease; nephrotic syndrome

Journal Article.  1353 words.  Illustrated.

Subjects: Nephrology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.