Journal Article

Low serum magnesium is associated with decreased graft survival in patients with chronic cyclosporin nephrotoxicity

Ryan Holzmacher, Christina Kendziorski, R. Michael Hofman, Jonathan Jaffery, Bryan Becker and Arjang Djamali

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 20, issue 7, pages 1456-1462
Published in print July 2005 | ISSN: 0931-0509
Published online April 2005 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfh831
Low serum magnesium is associated with decreased graft survival in patients with chronic cyclosporin nephrotoxicity

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Background. Hypomagnesaemia is a common side effect of cyclosporin A (CsA) therapy. Animal studies suggest that magnesium (Mg) supplementation inhibits chronic CsA nephropathy.

Methods. To determine if low Mg levels correlate with true CsA-induced nephrotoxicity in humans, we examined kidney transplant biopsy records at our centre for all transplant biopsies performed between 1990 and 2002. We simultaneously reviewed the medical records to determine whether serum Mg levels were checked at the time of biopsy. Those individuals with histologically proven CsA nephrotoxicity were studied.

Results. Serum total Mg levels were available for 320 patients, 60 of whom were diagnosed with chronic CsA-mediated nephropathy. Patients were divided in two groups, a low Mg [n = 29, 1.8 (1.67–1.9) mg/dl or 0.74 (0.68–0.78) mmol/l] and a normal Mg group [n = 31, 2.2 (2.0–2.4) mg/dl or 0.9 (0.82–0.98) mmol/l, P<0.05] based on the median Mg level in the entire cohort (2 mg/dl or 0.82 mmol/l). Both groups were analysed for disease progression and graft loss using the slope of creatinine clearance (CCR) and multivariate analyses. Although the CCR at the time of biopsy was greater in the low Mg group [44.3 (36.3–64.3) ml/min vs 37.8 (25.2–47.3) ml/min, P<0.05), the decline in graft function was faster in this group (−8.9±3.5 vs 1±2.7 ml/min/year; P = 0.02) compared with the normal Mg cohort. Using Cox proportional hazards analyses, the adjusted graft survival was significantly reduced in the low Mg group 5 years after biopsy.

Conclusions. Our study demonstrates that low serum Mg levels were associated with a faster rate of decline in kidney allograft function and increased rates of graft loss in renal transplant recipients with chronic CsA nephropathy. This suggests that hypomagnesaemia could potentiate CsA-mediated nephropathy.

Keywords: allograft; cyclosporin; kidney; magnesium; outcomes; transplantation

Journal Article.  3801 words.  Illustrated.

Subjects: Nephrology

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