Journal Article

Circulating resistin concentrations in children depend on renal function

Kai-Dietrich Nüsken, Jürgen Kratzsch, Veronica Wienholz, Wolfgang Stöhr, Wolfgang Rascher and Jörg Dötsch

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 21, issue 1, pages 107-112
Published in print January 2006 | ISSN: 0931-0509
Published online September 2005 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfi084
Circulating resistin concentrations in children depend on renal function

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Background. Resistin is a newly discovered peptide hormone that inhibits adipogenesis. Furthermore, it may be involved in regulative processes taking place in insulin resistance and inflammation. In human beings as well as in rodents, the exact physiological role of resistin is unknown. The objective of this study was to examine whether resistin serum concentrations in childhood are regulated by renal function.

Methods. Fifteen patients with end stage renal disease treated by haemodialysis (HD) (6m, 9f; age (median (25–75% percentile)) 16.1 (14.2–16.9) years; body mass index (BMI) 17.8 (17.6–20.6) kg/m2; glomerular filtration rate (GFR)<10 ml/min/1.73 m2), 11 patients with chronic renal failure (CRF) (4m, 7f; age 11.3 (9.2–16.9) years; BMI 17.9 (15.4–22.1) kg/m2; GFR 21.2 (19.8–39.4) ml/min/1.73 m2) and 23 healthy children (13m, 10f; age 7.8 (4.7–14.5) years; BMI 16.5 (14.9–18.1) kg/m2; GFR 168.5 (154.0–197.2) ml/min/1.73 m2) were included. Resistin concentration in serum was measured by ELISA, leptin by RIA.

Results. Resistin concentrations were significantly elevated in HD (6.6 (5.7–8.7) ng/ml) and CRF (4.8 (4.1–6.2) ng/ml) compared to healthy controls [2.7 (2.0–3.6) ng/ml; P<0.0001 by multiple regression analysis]. Furthermore, resistin concentrations showed a tendency to be higher in children below the age of 5.5 years (youngest tertile) and above 12.5 years of age (oldest tertile), compared to children aged between 5.5 and 12.5 years (P = 0.053 and P = 0.043, respectively). Gender (P = 0.686) and BMI (P = 0.663) did not have a significant influence on resistin concentrations. Resistin and leptin serum concentrations correlated in HD patients only (r = 0.62, P = 0.013 by Spearman correlation). Haemodialysis did not eliminate resistin.

Conclusions. With decreasing renal function, resistin concentration in serum increases in our small paediatric cohort. Age possibly influences circulating resistin concentration. The hypothesis that elevated serum resistin in children with chronic renal failure or end stage renal disease may add to malnutrition and reduced BMI needs further investigation and is not supported by our data.

Keywords: children; chronic renal failure; end stage renal disease; haemodialysis; resistin

Journal Article.  3555 words.  Illustrated.

Subjects: Nephrology

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