Journal Article

Pulse pressure and inhibition of renin–angiotensin system in chronic kidney disease

Debasish Banerjee, Stephan Brincat, Helen Gregson, Gabriel Contreras, Chris Streather, David Oliveira and Stephen Nelson

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 21, issue 4, pages 975-978
Published in print April 2006 | ISSN: 0931-0509
Published online December 2005 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfi345
Pulse pressure and inhibition of renin–angiotensin system in chronic kidney disease

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Background. Elevated pulse pressure (PP) is an indicator of poor outcome in hypertensives in the general population and on haemodialysis. The prognostic value of PP in pre-dialysis patients with chronic kidney disease (CKD) stages 4/5 and its interaction with renin–angiotensin system (RAS) inhibitors is unknown.

Methods. This retrospective study of 349 patients from the pre-dialysis clinic analysed the effect association of PP and RAS inhibition on adverse outcomes in CKD stages 4/5. Primary endpoints were a composite of death or dialysis.

Results. At baseline, 349 patients (63% males, 34% diabetics) were aged 60±0.8 years (mean±SEM) with systolic blood pressure (SBP) 149±1.3 mmHg, diastolic BP (DBP) 83±0.7 mmHg, PP 66± 1.0 mmHg, creatinine 442±16 μmol/l and haemoglobin 10.7±0.1 g/dl. Patients were followed up for 297±19 days and 93% took one to seven (2.45±0.07) antihypertensives. At presentation, the adverse outcome group had higher SBP (151±1.5 vs 145±2.4 mmHg; P<0.05), proportion of diabetes (39% vs 23%; P<0.05) and creatinine (478±22 vs 354±11 μmol/l; P<0.05), but lower haemoglobin (10.6±0.1 vs 11.2±0.2 g/dl; P<0.05). PP increased with age (r2: 0.4; P<0.0001). PP >80 mmHg was associated with adverse outcome (Kaplan–Meier survival analysis, log-rank test P<0.05). In a model of proportional hazards regression, adjusted for age, baseline creatinine, diabetes and haemoglobin, elevated PP was associated with poorer outcome (hazards ratio: 1.09; 95% confidence interval: 1.01–1.18; P<0.05) and angiotensin-converting enzyme inhibitor/angiotensin-receptor blocker use was beneficial (hazards ratio: 0.73; 95% confidence interval: 0.53–0.99; P<0.05).

Conclusions. The study demonstrates that elevated PP indicates high risk of death or dialysis and the benefit of blockade of the RAS is independent of the baseline PP in patients with CKD stages 4/5.

Keywords: chronic kidney disease; pulse pressure; renin–angiotensin system; hypertension; ACE inhibitors; renal failure

Journal Article.  2382 words.  Illustrated.

Subjects: Nephrology

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