Journal Article

Serum calcium, phosphate, parathyroid hormone, albumin, aluminium and cholesterol achievement on replacement therapy (Chapter 9)

Edmund J Lamb, Alex Hodsman, Dirk van Schalkwyk, David Ansell and Graham Warwick

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 22, issue suppl_7, pages vii105-vii118
Published in print August 2007 | ISSN: 0931-0509
Published online August 2007 | e-ISSN: 1460-2385 | DOI:
Serum calcium, phosphate, parathyroid hormone, albumin, aluminium and cholesterol achievement on replacement therapy (Chapter 9)

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In the UK, there is a continuing year-on-year trend towards improvement in serum phosphate control in dialysis patients although overall it still remains poor. The Renal Association (RA) target (<1.8 mmol/l) was achieved in 65% of patients overall, (71% of peritoneal dialysis (PD) patients, 63% of haemo dialysis (HD) patients).

Seventy-six percent of UK dialysis patients achieve a corrected calcium concentration within the RA target range. As with serum phosphate, there is a trend of continuing year-on-year improvement.

Nearly two-thirds (69%) of patients achieve a calcium × phosphate product within the KDOQI guidelines (<4.4 mmol2/l2): again, achievement seems to have improved year-on-year. Control was better in PD patients compared with HD patients (73% vs 67% achieving the standard).

There remains large between-centre variation in the ability of renal centres to achieve the UK RA target for plasma parathyroid hormone (PTH). As seen in previous years, overall achievement was poor (median 63%, range 47–92% compliance with the standard).

Most transplant patients achieve good phosphate and calcium control (99%, range 95–100%) and the percentage of patients achieving serum calcium concentrations within the target range was 84% (range 43–97%). Nearly all (99%) of transplant patients achieved calcium × phosphate product concentrations within the KDOQI target range.

There would appear to be wide variation in clinical practice with respect to aluminium monitoring with a suggestion that few centres are following current UK, RA guidelines.

Overall in the UK, 83% of HD, 70% of PD and 62% of transplant patients achieve a total cholesterol concentration <5 mmol/l. The percentage of patients with cholesterol <5 mmol/l has increased significantly year-on-year in all three modalities

Journal Article.  4685 words.  Illustrated.

Subjects: Nephrology

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