Journal Article

Lack of association between thrombosis-associated and cytokine candidate gene polymorphisms and acute rejection or vascular complications after kidney transplantation

Noora S. Alakulppi, Lauri E. Kyllönen, Jukka Partanen, Kaija T. Salmela and Jarmo T. Laine

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 23, issue 1, pages 364-368
Published in print January 2008 | ISSN: 0931-0509
Published online August 2007 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfm528
Lack of association between thrombosis-associated and cytokine candidate gene polymorphisms and acute rejection or vascular complications after kidney transplantation

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Background. Acute rejection episodes and vascular complications are common after renal transplantation and have negative impact on the long-term patient and graft survival. We investigated whether the risks of acute rejection, thrombosis, infarction and graft loss could be predicted based on the presence of functional polymorphisms in the genes of the coagulation and endothelial inflammation cascade.

Methods. The study consisted of 772 consecutive cadaver kidney transplantations from a single centre. The effects of gene polymorphisms FVL, F5R2, FII G20210A, MTHFR C677T, F13A1 V34L, TFPI P151L, PROC W380G, TNF G(-308)A, IL10 A(-592)C, IL10 A(-1082)G and IL6 C(-174)G of recipients and donors were investigated.

Results. We were unable to find statistically significant associations between any of the studied polymorphisms and clinical outcomes.

Conclusions. Our results indicate that high-risk renal transplant candidates cannot be identified through the routine analysis of the polymorphisms.

Keywords: infarction; kidney transplantation; polymorphism; rejection; thrombosis

Journal Article.  3217 words. 

Subjects: Nephrology

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