Journal Article

Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature

Arash Nickkholgh, Jürgen Weitz, Jens Encke, Peter Sauer, Arianeb Mehrabi, Markus W. Büchler, Jan Schmidt and Peter Schemmer

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 22, issue suppl_8, pages viii29-viii36
Published in print September 2007 | ISSN: 0931-0509
Published online September 2007 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfm654
Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature

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Organ shortage has driven many transplant programs to extend their criteria to accept donors. The goal of the present work is to further characterize the most important extended donor criteria (EDC) in liver transplantation and to identify factors that impact outcomes for this type of grafts through a comprehensive review of the most recent findings and current opinions. Age, steatosis, positive viral hepatitis serology, intensive care unit stay, and history of malignancy in donor have been the matter of substantial debate in recent years and are therefore discussed in further detail here. Cold and warm ischemic times have also been discussed separately as they have been identified as important independent risk factors for mortality. The use of grafts with EDC provides an immediate expansion of the donor pool. However, in order to optimize effective utilization of EDC, attempts should be made to carefully match the most appropriate graft-recipient pair.

Keywords: liver transplantation; extended donor criteria; graft survival; patient survival; donor age; steatosis; hepatitis; malignancy; ischemia time

Journal Article.  5277 words.  Illustrated.

Subjects: Nephrology

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