Journal Article

Preventive effect of nebivolol on contrast-induced nephropathy in rats

Omer Toprak, Mustafa Cirit, Mehmet Tanrisev, Cevat Yazici, Ozlem Canoz, Murat Sipahioglu, Atilla Uzum, Rifki Ersoy and Eser Yildirim Sozmen

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 23, issue 3, pages 853-859
Published in print March 2008 | ISSN: 0931-0509
Published online October 2007 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfm691
Preventive effect of nebivolol on contrast-induced nephropathy in rats

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Background. Altered renal vasodilatation and oxidative stress are important mechanisms of contrast-induced nephropathy (CIN). The aim of the present study was to assess the effect of nebivolol, a beta blocker, on prevention of CIN. We hypothesized that nebivolol may prevent CIN due to its renal vasodilatation and antioxidant effects.

Methods. Thirty-two Wistar-albino rats were divided into four groups (n = 8 each): control (C), contrast media (CM), nebivolol (N), and nebivolol + contrast media (NCM). CIN was induced by administration of intravenous high-osmolar contrast media diatrizoate (6 ml/kg) after 72 h of dehydration. Nebivolol (2 mg/kg) was given internally once daily for 5 days. Kidney function parameters, nitric oxide metabolites and oxidative stress markers were measured. Kidneys were excised for pathological evaluation.

Results. The decrease of creatinine clearance was 0.180 ± 0.11 mg/dl in CM, and 0.030 ± 0.10 mg/dl in NCM (P = 0.01). Microproteinuria was ameliorated using nebivolol (P = 0.001). Serum protein carbonyl content, malonyldialdehyde and kidney thiobarbituric acid-reacting substances levels were higher in CM than in C (P = 0.003, P < 0.001 and P = 0.034, respectively) and serum thiol was lower in CM than in C (P = 0.001). However, oxidative stress markers were similar in NCM and C. Diatrizoate decreased kidney nitrite levels, but nebivolol increased them (P = 0.027). Nebivolol attenuated the tubular necrosis, proteinaceous casts and medullary congestion, although significant protective effects, were observed in tubular necrosis (P = 0.001) and proteinaceous cast (P < 0.001).

Conclusion. This study demonstrated the protective role of nebivolol against CIN.

Keywords: contrast-induced nephropathy; contrast media; nebivolol; nitric oxide; oxidative stress

Journal Article.  4484 words.  Illustrated.

Subjects: Nephrology

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