Journal Article

Correlates of ACE activity in macroalbuminuric type 2 diabetic patients treated with chronic ACE inhibition

Abdolrahim Nikzamir, Manouchehr Nakhjavani, Alireza Esteghamati and Armin Rashidi

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 23, issue 4, pages 1274-1277
Published in print April 2008 | ISSN: 0931-0509
Published online November 2007 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfm745
Correlates of ACE activity in macroalbuminuric type 2 diabetic patients treated with chronic ACE inhibition

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The activity of the renin–angiotensin–aldosterone system (RAAS) plays an important role in the development and progression of diabetic nephropathy. However, the effect of angiotensin-converting enzyme (ACE) inhibition on the RAAS appears to be modulated by a number of factors including the I/D polymorphism of the ACE genotype. In this study, we attempted to find independent correlates of ACE activity in 121 macroalbuminuric type 2 diabetic Iranian patients under chronic ACE inhibition. Both univariate and multivariate analyses were used. The presence of the D allele was independently associated with significantly higher levels of ACE activity (with the II genotype as reference, P < 0.001, B = 27.3, 95% CI = 17.6–37.1), and this association was not eliminated by potentially confounding variables. In conclusion, the D allele is a significant independent correlate of ACE activity in macroalbuminuric type 2 diabetic Iranian patients under long-term ACE inhibition.

Keywords: ACE activity; diabetic nephropathy; macroalbuminuria; polymorphism; type 2 diabetes

Journal Article.  2851 words. 

Subjects: Nephrology

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