Journal Article

Coronary artery bypass surgery and acute kidney injury—impact of the off-pump technique

Parwis Massoudy, Soeren Wagner, Matthias Thielmann, Ulf Herold, Eva Kottenberg-Assenmacher, Günther Marggraf, Andreas Kribben, Thomas Philipp, Heinz Jakob and Stefan Herget-Rosenthal

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 23, issue 9, pages 2853-2860
Published in print September 2008 | ISSN: 0931-0509
Published online April 2008 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfn153
Coronary artery bypass surgery and acute kidney injury—impact of the off-pump technique

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Background. Acute kidney injury (AKI) is a serious and frequent complication after coronary artery bypass grafting (CABG). Cardiopulmonary bypass (CPB) was identified as a major AKI risk factor after CABG. Our aim was to assess the impact of the off-pump coronary artery bypass (OPCAB) compared to the on-pump coronary artery bypass (ONCAB) technique on the rate and severity of AKI, while taking other risk factors for AKI into account.

Methods. An observational study of 201 consecutive adult patients was conducted; 100 were operated by the OPCAB and 101 by the ONCAB technique. All patients in each group were operated by a single, experienced surgeon. Fifteen pre-, intra- and postoperative variables that were repeatedly identified in previous studies as independent AKI risk factors were included in this analysis. AKI was defined as an increase of serum creatinine ≥50% or ≥0.3 mg/dL within 48 h and AKI severity was classified, according to current AKIN definitions.

Results. Significantly fewer OPCAB patients developed AKI compared to ONCAB (14.0 versus 27.7%; P = 0.03). OPCAB was associated with milder stages of AKI, whereas ONCAB patients had more severe AKI. Congestive heart failure and chronic kidney disease were independent risk factors for AKI. The OPCAB technique for CABG was identified as the only independent factor associated with lower incidence of AKI.

Conclusions. Using current AKI definitions and classifications, the OPCAB technique for CABG, which avoids CPB; was associated with a significantly lower rate and less severe AKI compared to ONCAB. The OPCAB technique was identified as the only modifiable and potentially protective factor against postoperative AKI.

Keywords: acute kidney injury; acute renal failure; cardiopulmonary bypass; coronary artery bypass grafting; off-pump coronary artery bypass

Journal Article.  5412 words. 

Subjects: Nephrology

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