Journal Article

The HLA-DRB1<sup>*</sup>1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease

Wataru Kitagawa, Hirokazu Imai, Atsushi Komatsuda, Nobuki Maki, Hideki Wakui, Yoshiyuki Hiki and Satoshi Sugiyama

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 23, issue 10, pages 3126-3129
Published in print October 2008 | ISSN: 0931-0509
Published online April 2008 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfn179
The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease

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Background. We aimed to clarify the relationship between HLA-DRB1*1501 and anti-glomerular basement membrane (GBM) antibody-mediated disease in Japanese patients.

Materials. Samples were collected from 16 anti-GBM antibody-positive patients who were admitted to our department or related hospitals from December 1990 to October 2005. We analysed clinical and laboratory data, kidney biopsy findings, and the HLA-DR phenotypes and HLA-DRB1 alleles of the patients.

Results. Among the 16 patients, 15 had HLA-DR15 [the phenotype frequency (PF) was 93.8%], 7 were positive for DR4 (the PF was 43.8%) and 5 were positive for DR9 (the PF was 31.3%). The allele frequency of HLA-DRB1*1501 was 46.4% (13/28), which was significantly different from Japanese controls (11.6%) (P < 0.001). In contrast, the frequency of HLA-DRB1*1502 was not different from controls (0/28). The odds ratio of HLA-DRB1*1501 in these patients was 6.4 (95% CI: 2.4–16.5).

Conclusion. The present study demonstrated that Japanese patients with anti-GBM antibody-mediated disease are very likely to carry the HLA-DRB1*1501 but not the HLA-DRB1*1502 allele.

Keywords: anti-glomerular basement membrane antibody; Goodpasture's disease; HLA-DR15; HLA-DRB1*1501

Journal Article.  2101 words. 

Subjects: Nephrology

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