Journal Article

Cholesteryl ester transfer protein activity and cardiovascular events in patients with chronic kidney disease stage V

Sarah Seiler, Axel Schlitt, Xian-Cheng Jiang, Christof Ulrich, Stefan Blankenberg, Karl J. Lackner, Matthias Girndt, Karl Werdan, Michael Buerke, Danilo Fliser and Gunnar H. Heine

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 23, issue 11, pages 3599-3604
Published in print November 2008 | ISSN: 0931-0509
Published online May 2008 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfn296
Cholesteryl ester transfer protein activity and cardiovascular events in patients with chronic kidney disease stage V

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Background. Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular events (CVE). Uraemic dyslipidaemia, which is characterized by low HDL-cholesterol (HDL-C) and elevated triglycerides’ levels, may contribute to this elevated cardiovascular risk. Cholesteryl ester transfer protein (CETP) lowers HDL-C by transferring cholesterol esters to LDL and VLDL particles. We tested the hypothesis that CETP activity is associated with CVE in patients with CKD stage V.

Methods. We measured CETP activity and cholesterol levels in 69 haemodialysis patients. CVE and death were prospectively assessed over a follow-up period of 48 months.

Results. CETP activity was negatively correlated with HDL-C levels in patients without lipid-lowering medication (r = −0.379, P = 0.005). We found no difference in CETP activity in patients with cardiovascular disease at baseline compared to patients without cardiovascular disease. The same was true for incident CVE during the follow-up. When stratifying patients by median CETP activity, patients with high CETP activity did not have an increased risk for CVE (P = 0.901 by the log-rank test) or death (P = 0.615). Similarly, after stratifying patients by median HDL-C no increased risk for CVE (P = 0.780) or death (P = 0.838) was found in patients with low HDL-C.

Conclusions. In summary, although CETP activity correlated with HDL-C levels, neither high CETP activity nor low HDL-C was associated with CVE in CKD stage V patients. Thus, pharmacological modification of HDL-C by CETP inhibitors seems to be of questionable value in these patients.

Keywords: CETP; chronic kidney disease; CV events; haemodialysis treatment; HDL

Journal Article.  2642 words.  Illustrated.

Subjects: Nephrology

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