Journal Article

Pharmacodynamic effects of cinacalcet after kidney transplantation: once- versus twice-daily dose

Nassim Kamar, Isabelle Gennero, Luciana Spataru, Laure Esposito, Joelle Guitard, Laurence Lavayssière, Olivier Cointault, Peggy Gandia, Dominique Durand and Lionel Rostaing

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 23, issue 11, pages 3720-3726
Published in print November 2008 | ISSN: 0931-0509
Published online June 2008 | e-ISSN: 1460-2385 | DOI: https://dx.doi.org/10.1093/ndt/gfn345
Pharmacodynamic effects of cinacalcet after kidney transplantation: once- versus twice-daily dose

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Background. In the setting of kidney transplantation, cinacalcet has been given, mainly, once daily, but also twice daily. The aims of this prospective study were to assess the acute pharmacodynamic effect of cinacalcet administrated once or twice daily to kidney transplant patients with normal renal function and persisting hypercalcaemia due to hyperparathyroidism and to evaluate 1-year efficacy and tolerance of cinacalcet given at a dose of 30 mg b.i.d.

Methods. Eleven patients, who received a transplant 6 (6–59) months previously, were included in the study. A first kinetic was done after administration of 60 mg of cinacalcet at 8 a.m. After a washout period of 1 week, the second kinetic was performed with cinacalcet given at 30 mg b.i.d within a 12-h period.

Results. During both kinetics, serum calcium (sCa), ionized calcium (sCa2+), albumin-corrected Ca and parathyroid hormone (PTH) levels decreased significantly. At 24 h after the second kinetic, sCa2+ was significantly lower. After 1 year of cinacalcet treatment, given at the dose of 30 mg b.i.d., there was a significant decrease in sCa, sCa2+, PTH levels and calcium × phosphorus (Ph) product. In contrast, Ph levels increased significantly. There was no significant change in renal function.

Conclusion. Once- or twice-daily acute administration of cinacalcet to kidney-transplant patients has similar efficacy. One-year administration of cinacalcet, given as two daily doses, is safe and efficient.

Keywords: cinacalcet; daily dose; hyperparathyroidism; renal function; renal transplantation

Journal Article.  4622 words.  Illustrated.

Subjects: Nephrology

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