Journal Article

Over-expression of colonic K<sup>+</sup> channels associated with severe potassium secretory diarrhoea after haemorrhagic shock

Marion Simon, Jean-Paul Duong, Vincent Mallet, Raymond Jian, Kenneth A. MacLennan, Geoffrey I. Sandle and Philippe Marteau

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 23, issue 10, pages 3350-3352
Published in print October 2008 | ISSN: 0931-0509
Published online July 2008 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfn411
Over-expression of colonic K+ channels associated with severe potassium secretory diarrhoea after haemorrhagic shock

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A 67-year-old woman with end-stage renal disease (ESRD) was referred with chronic diarrhoea, severe hypokalaemia and recurrent colonic pseudo-obstructions following haemorrhagic shock. The cause of secretory diarrhoea was uncertain, but an ileostomy identified the colon as the source of the watery diarrhoea and potassium (K+) losses, and symptoms only resolved after colectomy. Immunohistochemistry of the colon revealed over-expression of high conductance K+ (BK) channel protein in surface colonocytes and crypt cells compared with controls and other patients with ESRD. We hypothesize that colonic ischaemia during haemorrhagic shock led to increased BK channel expression and thus enhanced colonic K+ and water secretion, resulting in severe hypokalaemia and colonic pseudo-obstruction.

Keywords: colonic K+ channel; colonic K+ secretion; ischaemic colitis; secretory diarrhoea

Journal Article.  984 words.  Illustrated.

Subjects: Nephrology

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