Journal Article

A syndrome resembling Bartter's syndrome in sarcoidosis

Tung-Min Yu, Shih-Hua Lin, Chuang Ya-Wen, Mei-Chin Wen, Yi-Hsing Chen, Chi-Hung Cheng, Cheng-Hsu Chen, Chung-Shi Chin and Kuo-Hsiung Shu

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 24, issue 2, pages 667-669
Published in print February 2009 | ISSN: 0931-0509
Published online November 2008 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfn600
A syndrome resembling Bartter's syndrome in sarcoidosis

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Acquired Bartter-like syndrome, albeit rare, has not been reported to be associated with sarcoidosis. We describe the case of a 32-year-old male patient who presented with progressive muscular weakness of both lower extremities. Profound hypokalaemia associated with renal (K+) wasting, bilateral nephrocalcinosis and high plasma renin activity resembled Bartter's syndrome (BS). Both mediastinal lymph node and renal biopsy demonstrated sarcoidosis with non-caseating granuloma. Genetic testing responsible for hereditary BS or Gitelman's syndrome (GS) was negative. Hypokalaemia was well controlled with the administration of spironolactone with oral steroids and KCl. Early recognition and prompt treatment of sarcoidosis-associated Bartter-like syndrome avoids unnecessary complications.

Keywords: acquired Bartter-like syndrome; hypokalaemia; sarcoidosis

Journal Article.  1393 words.  Illustrated.

Subjects: Nephrology

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