Journal Article

Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease

Elizabeth C. Lorenz, Sanjeev Sethi, Tanya L. Poshusta, Marina Ramirez-Alvarado, Shaji Kumar, Donna J. Lager, Fernando C. Fervenza and Nelson Leung

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 25, issue 4, pages 1340-1343
Published in print April 2010 | ISSN: 0931-0509
Published online January 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfp735
Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease

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Renal dysfunction commonly occurs in multiple myeloma (MM) and is caused by deposition of abnormal light chain within various compartments of the kidney. Renal pathologic findings are diverse and include cast nephropathy (CN), amyloidosis and light-chain deposition disease (LCDD). We report a case of renal failure in a patient with MM caused by concurrent CN, amyloidosis and LCDD which has not been previously described.

Keywords: amyloidosis; light chain; myeloma; nephropathy

Journal Article.  2111 words.  Illustrated.

Subjects: Nephrology

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