Journal Article

Simultaneous evaluation of renal morphology and function in live kidney donors using dynamic magnetic resonance imaging

F. Artunc, S. Yildiz, C. Rossi, A. Boss, H. Dittmann, H.P. Schlemmer, T. Risler and N. Heyne

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 25, issue 6, pages 1986-1991
Published in print June 2010 | ISSN: 0931-0509
Published online January 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfp772
Simultaneous evaluation of renal morphology and function in live kidney donors using dynamic magnetic resonance imaging

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Background. Evaluation of potential kidney donors requires the assessment of both kidney anatomy and function. In this prospective study, we sought to expand the diagnostic yield of magnetic resonance (MR) by adding functional measurements of glomerular filtration rate (GFR) and split renal function.

Methods. Between 2007 and 2009, all potential kidney donors presenting to our facility underwent a comprehensive single-stop MR study that included an assessment of anatomy, angiography and functional measurements. GFR was measured after a bolus injection of gadobutrol (4 ml, ∼0.05 mmol/kg) and calculated from the washout of the signal intensity obtained over the liver. Split renal function was calculated from the increase of signal intensity over the renal cortex. Values were compared to renal scintigraphy with 99mTc-DTPA from the same day.

Results. The MR investigation was successfully performed in 21 participants. The GFR derived from MR (MR-GFR) correlated well (r = 0.84) with the GFR derived from scintigraphy (DTPA-GFR). The mean value of the paired differences was 4 ± 13 [SD] ml/min/1.73 m2 and was not significantly different from zero. The ratio between right and left kidney function was similar with both techniques (1.01 ± 0.17 with MR and 1.06 ± 0.12 with scintigraphy, P = 0.20).

Conclusions. We demonstrate an MR-based approach to comprehensively evaluate both kidney anatomy and function in a single investigation, thereby facilitating the evaluation of potential kidney donors.

Keywords: donor evaluation; GFR; kidney transplantation; MR; scintigraphy

Journal Article.  3951 words.  Illustrated.

Subjects: Nephrology

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