Journal Article

A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13

Margrith E. Knecht, Michael Mayr, Silvia Ferrari, Friedrich Scheiflinger and Marten Trendelenburg

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 25, issue 5, pages 1720-1722
Published in print May 2010 | ISSN: 0931-0509
Published online January 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq021
A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13

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In this case report, we describe for the first time a patient with thrombotic thrombocytopaenic purpura (TTP) accompanying highly active systemic lupus erythematosus (SLE) that was associated with non-neutralizing antibodies against the plasma metalloprotease ADAMTS13. Those non-neutralizing antibodies could have been the cause of ADAMTS13 depletion and consecutive TTP. More extensive analyses are required to determine the prevalence as well as the clinical relevance of non-neutralizing antibodies against ADAMTS13 in SLE patients.

Keywords: ADAMTS13; autoantibodies; SLE; TTP

Journal Article.  1773 words. 

Subjects: Nephrology

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