Journal Article

Post-transplant lymphoproliferative disorder in view of the new WHO classification: a more rational approach to a protean disease?

Krzysztof Mucha, Bartosz Foroncewicz, Bogna Ziarkiewicz-Wróblewska, Marek Krawczyk, Jan Lerut and Leszek Pączek

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 25, issue 7, pages 2089-2098
Published in print July 2010 | ISSN: 0931-0509
Published online July 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq231
Post-transplant lymphoproliferative disorder in view of the new WHO classification: a more rational approach to a protean disease?

Show Summary Details

Preview

Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of solid-organ transplantation (SOT) and bone marrow transplantation leading to a high mortality (30–60%). PTLD represents a heterogeneous group of lymphoproliferative diseases. They become clinically relevant because of the expansion of transplantation medicine together with the development of potent immunosuppressive drugs. Although the diagnostic morphological criteria of different forms of PTLD are commonly known, rapid and correct diagnosis is not always easy. Because of the limited number of clinical trials, a consensus is lacking on the optimal treatment of PTLD. This review focuses on incidence, risk factors, clinical picture of the disease and diagnostic tools including histopathology relating to the new classification introduced in 2008 by the World Health Organisation (WHO) and treatment of PTLD.

Keywords: EBV; histopathology; PTLD; SOT; transplantation

Journal Article.  6155 words.  Illustrated.

Subjects: Nephrology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.