Journal Article

Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus

Huseyin Kadikoy, Michael Paolini, Katafan Achkar, Wadi Suki, A. Osama Gaber, Nabeel Anwar, Abdallah Jeroudi, Roberto Barrios and Abdul Abdellatif

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 25, issue 8, pages 2795-2798
Published in print August 2010 | ISSN: 0931-0509
Published online May 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq265
Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus

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Pulmonary alveolar proteinosis (PAP) has been associated with the immunosuppressant sirolimus in transplant patients. PAP is a progressive lung disease characterized by the accumulation of surfactant-like material in the lungs leading to decreased pulmonary function with shortness of breath and cough as common symptoms. We report a rare case of sirolimus-associated PAP in a kidney transplant recipient with a history of end-stage renal disease secondary to haemolytic uraemic syndrome (HUS) and review of the literature. Discontinuation of sirolimus and initiation of tacrolimus led to resolution of PAP without recurrence of HUS.

Keywords: haemolytic uraemic syndrome; kidney transplant; pulmonary alveolar proteinosis; sirolimus; tacrolimus

Journal Article.  1564 words.  Illustrated.

Subjects: Nephrology

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