Journal Article

Can mycophenolic acid dose requirement during the first transplant help predict dosing for the second transplant?

Vellaichamy M. Annapandian, Gopal Basu, Binu S. Mathew, Denise H. Fleming, Chakko K. Jacob and George T. John

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 25, issue 10, pages 3449-3452
Published in print October 2010 | ISSN: 0931-0509
Published online July 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq436
Can mycophenolic acid dose requirement during the first transplant help predict dosing for the second transplant?

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We describe the pharmacokinetic profile of mycophenolic acid (MPA) in a patient receiving Mycophenolate mofetil (MMF) during her first and second renal transplantations. The MMF dose required to achieve a therapeutic range of MPA-AUC012h early following the second transplantation was 10 times greater than that required late following the first transplantation. Her MMF requirement then declined and continued to decrease even beyond 1 year. Intra-individual variability in MPA profiles precluded the ability to predict MMF dosing for the second transplant based on that during the first. Therapeutic drug monitoring of MMF should be continued beyond 1 year of transplantation.

Keywords: intra-individual variability; mycophenolic acid; pharmacokinetics; renal transplantation; therapeutic drug monitoring

Journal Article.  1471 words.  Illustrated.

Subjects: Nephrology

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