Journal Article

The link between bone and coronary calcifications in CKD-5 patients on haemodialysis

Gulay Asci, Ercan Ok, Recep Savas, Mehmet Ozkahya, Soner Duman, Huseyin Toz, Meral Kayikcioglu, Adam J. Branscum, Marie-Claude Monier-Faugere, Johann Herberth and Hartmut H. Malluche

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 3, pages 1010-1015
Published in print March 2011 | ISSN: 0931-0509
Published online August 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq491
The link between bone and coronary calcifications in CKD-5 patients on haemodialysis

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Background. Vascular calcifications are frequent in Stage 5 chronic kidney disease (CKD-5) patients receiving haemodialysis. The current study was designed to evaluate the associations between bone turnover/volume and coronary artery calcifications (CAC).

Methods. In 207 CKD-5 patients, bone biopsies, multislice computed tomography of the coronary arteries and blood drawings for relevant biochemical parameters were done. The large number of CKD-5 patients enrolled allowed separate evaluation of patients with CAC versus patients without CAC and adjustment for traditional and non-traditional risk factors for CAC.

Results. When all patients were analysed, associations were found between CAC and bone turnover, bone volume, age, gender and dialysis vintage. When only patients with CAC were included, there was a U-shaped relationship between CAC and bone turnover, whilst the association with bone volume was lost. In these patients, the relationship of CAC with age, gender and dialysis vintage remained.

Conclusions. Beyond the non-modifiable risk factors of age, gender and dialysis vintage, these data show that bone abnormalities of renal osteodystrophy amenable to treatment should be considered in the management of patients with CAC.

Keywords: bone turnover; bone volume; coronary calcifications; dialysis; renal osteodystrophy

Journal Article.  3831 words. 

Subjects: Nephrology

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