Journal Article

Evolution of renal oxygen content measured by BOLD MRI downstream a chronic renal artery stenosis

Nicolas Rognant, Fitsum Guebre-Egziabher, Justine Bacchetta, Marc Janier, Bassem Hiba, Jean Baptiste Langlois, Rudy Gadet, Maurice Laville and Laurent Juillard

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 4, pages 1205-1210
Published in print April 2011 | ISSN: 0931-0509
Published online September 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq538
Evolution of renal oxygen content measured by BOLD MRI downstream a chronic renal artery stenosis

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Background. A decrease in renal oxygen content can be measured non-invasively by the increase of the R2* value derived from blood oxygen level-dependent magnetic resonance imaging (BOLD MRI). The aim of this study was to test if renal hypoxia occurs in kidneys downstream a chronic and unilateral renal artery stenosis.

Methods. Chronic renal ischaemia was induced in rats using a calibrated clip inserted on the right renal artery. R2* was determined, using a multiple recalled gradient-echo sequence, before and once a week after a clip insertion over 4 weeks, in a group of clipped (= 8) and sham-operated (= 7) rats.

Results. At baseline, in stenotic kidneys, R2* was higher in the outer stripe of outer medulla (105 ± 4.6) and the outer medulla (99 ± 2.5) than in the cortex (84 ± 2.5; P < 0.002 for comparison with both areas). R2* was unchanged in the cortex, the outer stripe of outer medulla and the outer medulla in stenotic kidneys, sham-operated kidneys and contralateral kidneys during the 4 weeks. Mean blood pressure was higher in rats with clipped kidney than in sham-operated rats from Day 11 and remained increased thereafter. The renal volume increased progressively in sham-operated kidneys and contralateral kidneys, whereas it slightly decreased in stenotic kidneys.

Conclusions. Our study shows that after 4 weeks, no renal hypoxia can be detected in the kidney downstream to a renal artery stenosis, suggesting that atrophy could be induced by other factors.

Keywords: Magnetic resonance imaging; Blood level oxygen dependent; Renal artery stenosis; Renal atrophy; Outer medulla

Journal Article.  4362 words.  Illustrated.

Subjects: Nephrology

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