Journal Article

Lethal varicella-zoster virus reactivation without skin lesions following renal transplantation

Jonathan Jantsch, Barbara Schmidt, Jürgen Bardutzky, Christian Bogdan, Kai-Uwe Eckardt and Ulrike Raff

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 1, pages 365-368
Published in print January 2011 | ISSN: 0931-0509
Published online September 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq542
Lethal varicella-zoster virus reactivation without skin lesions following renal transplantation

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Patients after solid organ transplantation are at increased risk of developing herpes zoster and are more likely to develop major complications such as cutaneous dissemination, post-herpetic neuralgia and visceral organ involvement. We report on a 68-year-old woman being varicella-zoster virus (VZV)-seropositive prior to transplantation, who developed fatal VZV meningoencephalitis after renal transplantation presenting with non-specific neurologic symptoms. The case illustrates that VZV reactivation may occur in renal transplant recipients in the absence of skin lesions. Approaches towards risk assessment pre-transplantation and prophylactic regimens for the prevention of VZV recurrence are needed.

Keywords: renal transplantation; varicella-zoster reactivation

Journal Article.  1741 words.  Illustrated.

Subjects: Nephrology

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