Journal Article

Glomerular diseases and transplantation: similarities in pathogenetic mechanisms and treatment options

Claudio Ponticelli, Rosanna Coppo and Maurizio Salvadori

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 1, pages 35-41
Published in print January 2011 | ISSN: 0931-0509
Published online September 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq574
Glomerular diseases and transplantation: similarities in pathogenetic mechanisms and treatment options

Show Summary Details

Preview

Glomerular diseases and renal transplantation have always been considered as independent fields of nephrology, due to the supposed prevalent role of antibody production and immune complex formation in glomerulonephritis versus a direct reaction of immune cell towards the grafted kidney. However, both conditions share common pathogenetical pathways, and possible new therapeutic approaches are being envisaged. Innate immunity, particularly Toll-like receptors, dendritic cells and complement pathways, B cells and antibody networks are involved in the development of glomerular damage as well as graft injury. Consequently, new treatments targeting previously not considered immune pathways, like nuclear factor-κB or the proteasome and B-cell activation with antibody production, are being tested in glomerular diseases and in transplanted kidneys.

Keywords: B cells; glomerulonephritis; innate immunity; renal transplantation; treatment

Journal Article.  5444 words. 

Subjects: Nephrology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.