Journal Article

Biomarkers in kidney and heart disease

Alan S. Maisel, Nevin Katz, Hans L. Hillege, Andrew Shaw, Pierluigi Zanco, Rinaldo Bellomo, Inder Anand, Stefan D. Anker, Nadia Aspromonte, Sean M. Bagshaw, Tomas Berl, Ilona Bobek, Dinna N. Cruz, Luciano Daliento, Andrew Davenport, Mikko Haapio, Andrew A. House, Sunil Mankad, Peter McCullough, Alexandre Mebazaa, Alberto Palazzuoli, Piotr Ponikowski, Federico Ronco, Geoff Sheinfeld, Sachin Soni, Giorgio Vescovo, Nereo Zamperetti and Claudio Ronco

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 1, pages 62-74
Published in print January 2011 | ISSN: 0931-0509
Published online October 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq647
Biomarkers in kidney and heart disease

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There is much symptomatic similarity between acute kidney disease and acute heart disease. Both may present with shortness of breath and chest discomfort, and thus it is not surprising that biomarkers of acute myocardial and renal disease often coexist in many physicians’ diagnostic work-up schedules. In this review we explore the similarities and differences between current and future tests of myocardial and renal injury and function, with particular emphasis on the diagnostic utility of currently available biomarkers to assist with the diagnosis of cardiorenal syndromes. Imaging studies have not traditionally been viewed as clinical biomarkers, but as tests of structure and function; they contribute to the diagnostic process, and we believe that they should be considered alongside more traditional biomarkers such as blood and urine measurements of circulating proteins and metabolites. We discuss the place of natriuretic peptides, novel tests of kidney damage as well as kidney function and conclude with a discussion of their place in guiding future research studies whose goals must include better characterization of the degree of dysfunction imposed on one organ system by failure of the other.

Keywords: acute kidney injury; cardiorenal syndromes; chronic kidney disease; decompensated heart failure

Journal Article.  7251 words.  Illustrated.

Subjects: Nephrology

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