Journal Article

Renal transplantation for nephrogenic systemic fibrosis: a case report and review of the literature

Madison C. Cuffy, Mansher Singh, Richard Formica, Evans Simmons, Ali K. Abu Alfa, Kacie Carlson, Michael Girardi, Shawn E. Cowper and Sanjay Kulkarni

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 3, pages 1099-1101
Published in print March 2011 | ISSN: 0931-0509
Published online November 2010 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq693
Renal transplantation for nephrogenic systemic fibrosis: a case report and review of the literature

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Nephrogenic systemic fibrosis (NSF) is a rare fibrosing disorder described among patients with renal disease. Currently, no standard therapy exists, although therapeutic modalities have included plasmapheresis, extracorporeal photopheresis, sodium thiosulphate, imatinib and renal transplantation. We describe a patient with NSF who was physically debilitated and underwent renal transplantation. After transplantation, the patient's lesions improved clinically, and the patient was ambulatory. Despite developing worsening renal function, her lesions remained unchanged. We conclude that renal transplantation improves symptoms of NSF, and believe that in patients with NSF, careful consideration should be made for early renal transplantation.

Keywords: end-stage renal disease (ESRD); gadolinium; nephrogenic systemic fibrosis; renal transplantation

Journal Article.  1275 words.  Illustrated.

Subjects: Nephrology

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