Journal Article

Device for continuous extracorporeal blood purification using target-specific metal nanomagnets

Inge K. Herrmann, Riccardo E. Bernabei, Martin Urner, Robert N. Grass, Beatrice Beck-Schimmer and Wendelin J. Stark

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 9, pages 2948-2954
Published in print September 2011 | ISSN: 0931-0509
Published online February 2011 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfq846
Device for continuous extracorporeal blood purification using target-specific metal nanomagnets

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Background. The present work illustrates how magnetic separation-based blood purification using ultra-strong iron nanomagnets can be implemented into an extracorporeal blood purification circuit. By this promising technique, today’s blood purification may be extended to specifically filter high-molecular compounds without being limited by filter cut-offs or column surface saturation.

Methods. Blood spiked with digoxin (small molecule drug) and interleukin-1β (inflammatory protein) was circulated ex vivo through a device composed of approved blood transfusion lines. Target-specific nanomagnets were continuously injected and subsequently recovered with the aid of a magnetic separator before recirculating the blood.

Results. Magnetic blood purification was successfully carried out under flow conditions: already in single-pass experiments, removal efficiencies reached values of 75 and 40% for digoxin and interleukin-1β, respectively. Circulating 0.5 L of digoxin-intoxicated blood in a closed loop, digoxin concentration was decreased from initially toxic to therapeutic concentrations within 30 min and purification extents of 90% were achieved after 1.5 h.

Conclusions. Magnetic separation can be successfully implemented into an extracorporeal blood purification device. Simultaneous and specific filtering of high-molecular compounds may offer promising new therapeutic tools for the future treatment of complex diseases, such as sepsis and autoimmune disorders.

Keywords: detoxification; dialysis; magnetic separation; nanoparticle; selective

Journal Article.  3839 words.  Illustrated.

Subjects: Nephrology

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