Journal Article

Clinically unexpected cyclosporine levels using the ACMIA method on the RXL dimension analyser

Johann Morelle, Pierre Wallemacq, Olivier Van Caeneghem and Eric Goffin

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 4, pages 1428-1431
Published in print April 2011 | ISSN: 0931-0509
Published online February 2011 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfr002
Clinically unexpected cyclosporine levels using the ACMIA method on the RXL dimension analyser

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Safe use of cyclosporine (CsA) in solid organ transplantation relies on regular whole-blood drug monitoring. Several promising immmunoassays, e.g. the antibody-conjugated magnetic immunoassay (ACMIA) method, were developed and commercialized during recent years to compete with liquid chromatography coupled to tandem mass spectrometry, which remains the reference method but is labor-intensive. We describe the occurrence of interference in the monitoring of whole-blood CsA after transplantation when using the ACMIA method and discuss the potential mechanisms involved in such interference. Clinically unexpected results of whole-blood CsA require immediate reassessment by another technique to prevent the risk of CsA underdosage and graft rejection.

Keywords: ACMIA; cyclosporine; drug monitoring; transplantation; interference

Journal Article.  2420 words.  Illustrated.

Subjects: Nephrology

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