Journal Article

Immune response to an adjuvanted influenza A H1N1 vaccine (Pandemrix®) in renal transplant recipients

Susanne Brakemeier, Brunhilde Schweiger, Nils Lachmann, Petra Glander, Constanze Schönemann, Fritz Diekmann, Hans-Hellmut Neumayer and Klemens Budde

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 1, pages 423-428
Published in print January 2012 | ISSN: 0931-0509
Published online May 2011 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfr278
Immune response to an adjuvanted influenza A H1N1 vaccine (Pandemrix®) in renal transplant recipients

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Background.

In the course of the influenza A H1N1 pandemic, transplanted patients were recommended to receive vaccination. In the present study, we evaluated the immune response to an adjuvanted influenza A H1N1 vaccine (Pandemrix®) in renal allograft recipients.

Methods.

Sixty patients and 22 healthy controls participated in a prospective observational study and received a single dose of Pandemrix®. H1N1 antibody titres as well as anti-HLA antibodies were determined before and after vaccination. In 19 patients, a booster vaccination was performed and the outcome of all vaccinated renal allograft recipients (n = 107) in our clinic was reviewed.

Results.

Two out of sixty patients had an elevated influenza A H1N1 titre before vaccination. Of the remaining 58 patients, only 20/58 (34.5%) developed a protective immune response in contrast to 20/22 (91%) of the control group. After booster vaccination, a protective titre was present in 8/19 (42%) of patients. Of the 107 patients, 6 (5.6%) developed new donor-specific HLA antibodies after vaccination.

Conclusions.

These data suggest that Pandemrix® does not provide a protective immune response in the majority of kidney transplant recipients. Therefore, for new vaccines, efficacy as well as safety profiles should be evaluated in this subgroup of patients.

Keywords: H1N1; HLA-antibodies; transplantation; vaccination

Journal Article.  3931 words.  Illustrated.

Subjects: Nephrology

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