Journal Article

Lyme disease-associated glomerulonephritis

Finnian R. Mc Causland, Sophie Niedermaier, Vanesa Bijol, Helmut G. Rennke, Mary E. Choi and John P. Forman

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 9, pages 3054-3056
Published in print September 2011 | ISSN: 0931-0509
Published online July 2011 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfr335
Lyme disease-associated glomerulonephritis

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We report two cases of Lyme disease-associated glomerulonephritis. A 57-year-old female presented with rash, volume overload, hypertension and rapidly progressive glomerulonephritis. Biopsy confirmed an immune complex-mediated, membranoproliferative lesion. She was treated successfully with steroids and antibiotics. In a second case, a 40-year-old male, with a previously known microscopic hematuria, presented with rash, arthralgias, new proteinuria and gross hematuria following a tick bite. Biopsy revealed focal proliferative IgA nephropathy. Treatment with steroids and antibiotics resulted in rapid resolution of findings. Acute Lyme disease may contribute to the development of de novo, or activation of previously quiescent, immune-mediated glomerular disease.

Keywords: glomerulonephritis; IgA; Lyme disease; membranoproliferative

Journal Article.  1299 words.  Illustrated.

Subjects: Nephrology

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