Journal Article

Acute renal failure with lambda light chain-derived crystals in a patient with IgD myeloma

Cécile Toly-Ndour, Julie Peltier, Rémi Piedagnel, Paul Coppo, Emmanuelle Sachon, Pierre Ronco, Eric Rondeau, Patrice Callard and Pierre Aucouturier

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 26, issue 9, pages 3057-3059
Published in print September 2011 | ISSN: 0931-0509
Published online July 2011 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfr377
Acute renal failure with lambda light chain-derived crystals in a patient with IgD myeloma

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Kidney involvement with immunoglobulin crystals usually relates to a light chain of the kappa type, in MGUS or smoldering myeloma, frequently causing Fanconi’s syndrome with progressive renal insufficiency. We report on a case with severe myeloma featuring lambda light chain-derived crystals and acute kidney injury. Histology showed acute tubular necrosis and tubule obstruction with crystals, which were also abundant inside tubule epithelial cells, macrophages and bone marrow plasma cells. The light chain variable domain had a normal overall primary structure but included 11 somatic mutations, 3 of which likely increased the surface hydrophobicity, as observed in previously reported kappa-type crystals.

Keywords: acute kidney injury; crystals; immunoglobulin light chain; myeloma

Journal Article.  1497 words.  Illustrated.

Subjects: Nephrology

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