Journal Article

A comparison of laboratory values in pediatric hemodialysis patients: does day of the week matter?

Christina Nguyen, Dale Bednarz, Michael E. Brier, Abubakr Imam and Deepa H. Chand

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 2, pages 816-819
Published in print February 2012 | ISSN: 0931-0509
Published online July 2011 | e-ISSN: 1460-2385 | DOI:
A comparison of laboratory values in pediatric hemodialysis patients: does day of the week matter?

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The National Kidney Foundation Dialysis Outcomes Quality Initiative (NKF-K/DOQI) guidelines recommend the delivered dose of hemodialysis (HD) be measured no less than monthly by checking Kt/V (K is effective urea clearance, t is minute and V is urea distribution). To date, no studies have explored whether the day of the week for checking maintenance HD laboratory studies impacts dialysis dosing.


Data were collected at two HD facilities on 19 patients, ages ≤21 years receiving maintenance HD thrice weekly over a consecutive 6-month period. Data obtained from the Monday and Wednesday of each full third week of the month included dialysis vintage, ultrafiltration volume, serum electrolytes, hemoglobin and clearances.


Kt/V and K+ were significantly different between Monday and Wednesday (P = 0.013 and P = 0.047, respectively).


Due to variability in values based on the day of laboratory evaluations, the dialysis provider must consider the impact of this on the quality of patient care when prescribing dialysis. Research on a larger scale needs to be conducted to allow for better decision-making capabilities in the chronic HD population.

Keywords: adequacy; electrolytes; hemodialysis; Kt/V

Journal Article.  2467 words. 

Subjects: Nephrology

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