Journal Article

Association of hepatitis C virus infection and malnutrition–inflammation complex syndrome in maintenance hemodialysis patients

Hung-Bin Tsai, Pau-Chung Chen, Chen-Hua Liu, Peir-Haur Hung, Mei-Tsu Chen, Chih-Kang Chiang, Jia-Horng Kao and Kuan-Yu Hung

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 3, pages 1176-1183
Published in print March 2012 | ISSN: 0931-0509
Published online September 2011 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfr458
Association of hepatitis C virus infection and malnutrition–inflammation complex syndrome in maintenance hemodialysis patients

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Background.

Patients undergoing maintenance hemodialysis (MHD) have a significantly higher prevalence of hepatitis C virus (HCV) infection and malnutrition–inflammation complex syndrome (MICS). In the present study of Taiwanese MHD patients, we determined the clinical characteristics and influence of HCV infection on MICS by calculation of the malnutrition–inflammation score (MIS).

Methods.

This was a prospective longitudinal study performed at a single hemodialysis (HD) center in Taiwan from September 2007 through March 2008. The study enrolled 58 patients (38%) in the active HCV group and 95 patients (62%) in the non-HCV group. The two or three weekly HD sessions of all patients were followed for 7 months. The MIS was assessed using 10 components, 7 from the conventional subjective global assessment of nutrition and 3 additional elements, body mass index, serum albumin and total iron-binding capacity.

Results.

HD vintage and total MIS score were greater in patients with active HCV. The active HCV group had significantly longer dialysis vintage and lower total cholesterol but higher total MIS score than the non-HCV group. The MIS 5 score, a measure of major comorbid conditions (including number of years on dialysis), was also significantly higher in the active HCV group.

Conclusion.

MHD patients with active HCV infections have more severe MICS-associated metabolic and physiological disease than MHD patients without active HCV infection.

Keywords: hepatitis C virus; maintenance hemodialysis; malnutrition–inflammation complex syndrome; malnutrition–inflammation score; subjective global assessment of nutrition

Journal Article.  4467 words.  Illustrated.

Subjects: Nephrology

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