Journal Article

Efficacy and safety of regional citrate anticoagulation in liver transplant patients requiring post-operative renal replacement therapy

Fuat H. Saner, Juergen W. Treckmann, Alexander Geis, Christian Lösch, Oliver Witzke, Ali Canbay, Stephan Herget-Rosenthal, Andreas Kribben, Andreas Paul and Thorsten Feldkamp

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 4, pages 1651-1657
Published in print April 2012 | ISSN: 0931-0509
Published online November 2011 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfr510
Efficacy and safety of regional citrate anticoagulation in liver transplant patients requiring post-operative renal replacement therapy

Show Summary Details

Preview

Background. Liver transplant patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) early post-operatively are at high risk for bleeding. Using heparin for anticoagulation during CRRT may contribute to the increased bleeding risk. Regional anticoagulation with citrate may decrease the risk of bleeding. However, citrate anticoagulation may be associated with metabolic complications in patients with liver impairment. The aim of the study was to evaluate the safety and efficacy of citrate anticoagulation in liver transplant patients.

Methods. All liver transplant recipients transplanted between November 2004 and August 2007, requiring CRRT and using citrate as the anticoagulant were included in this retrospective study. Demographic data, CRRT specific and metabolic data were collected and analysed.

Results. Sixty-eight patients (40 male/28 female) with a mean age of 47.1 ± 11.8 years and a Model of End-stage Liver Disease score of 23 ± 9 developed post-operative AKI requiring CRRT using citrate as the anticoagulant. The median duration on CRRT was 8 days (range 1–39 days) with a mean circuit life of 22.7 ± 14.6 h. There was no relevant time trend of serum sodium, potassium, calcium, bicarbonate and pH values during CRRT. Bleeding occurred in 8 of 68 (11.7%) patients during CRRT.

Conclusion. Regional citrate anticoagulation for CRRT in the early post-operative period after liver transplantation is effective and safe. Therefore, the general exclusion of citrate anticoagulation during CRRT in patients after liver transplantation is not justified.

Keywords: citrate anticoagulation; intensive care; liver transplantation; renal replacement therapy

Journal Article.  4891 words.  Illustrated.

Subjects: Nephrology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.