Journal Article

The association between plasma uric acid and renal function decline in a Chinese population-based cohort

Luxia Zhang, Fang Wang, Xingyu Wang, Lisheng Liu and Haiyan Wang

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 5, pages 1836-1839
Published in print May 2012 | ISSN: 0931-0509
Published online October 2011 | e-ISSN: 1460-2385 | DOI:
The association between plasma uric acid and renal function decline in a Chinese population-based cohort

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Uric acid may be associated with kidney damage through multiple pathways. Previous cohort studies revealed inconsistent results, and research among the non-hypertensive and non-diabetic population are extremely limited.


This prospective cohort study included 1410 residents aged 59.1 ± 9.4 years from an urban district of Beijing, China. All participants had an estimated glomerular filtration rate >60 mL/min/1.73m2. Plasma uric acid was assessed at baseline; and its relation with renal function decline after 4 years’ follow-up was analyzed.


During 4 years (5630 person-years) of follow-up, 168 patients (11.9%) developed renal function decline. After adjusting for potential confounders including baseline renal function, plasma uric acid levels were independently associated with an increased risk of renal function decline, with a fully adjusted odds ratio (OR) of 1.19 [per 1 mg/dL increase; 95% confidence interval (CI) 1.04–1.38]. Analysis among 615 hypertension-free and diabetes-free participants yielded similar results, with an adjusted OR of 1.50 (per 1 mg/dL increase; 95% CI 1.13–1.98).


Our prospective cohort study revealed that plasma uric acid level is independently associated with an increasing likelihood of renal function decline.

Keywords: chronic kidney disease; progression; uric acid

Journal Article.  2886 words. 

Subjects: Nephrology

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