Journal Article

What about the renal function during childhood of children born from dialysed mothers?

Pauline Abou-Jaoude, Laurence Dubourg, Lucie Bessenay, Adeline Pinçon, Anne Jolivot, Fitsum Guebre-Egziabher, Pierre Cochat and Justine Bacchetta

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 6, pages 2365-2369
Published in print June 2012 | ISSN: 0931-0509
Published online November 2011 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfr617
What about the renal function during childhood of children born from dialysed mothers?

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Introduction.

Pregnancy during dialysis is a high-risk condition which is becoming more and more common. The renal outcome of children born from such pregnancies needs to be investigated since renal development may be affected (i.e. exposure to uraemic toxins, therapies, intermittent haemodynamic changes during sessions, prematurity, growth retardation).

Methods.

We performed a single-centre prospective global and renal evaluation (inulin clearance or 2009 Schwartz formula in children <4 years) in 10 children from 7 mothers who underwent haemodialysis during pregnancy.

Results.

The median (range) age of mothers at the beginning of pregnancy was 30 (22–33) years, with maximal weekly haemodialysis duration of 18 (12–30) h. Systemic arterial hypertension was reported in 4 of 10 pregnancies, polyhydramnios in 3 and oligohydramnios in 1. The median (range) gestational age was 32 (29–39) weeks of gestation (WG). Seven children were born before 36 WG. The median (range) birth weight (BW) was 1735 (930–3430)g, and eight children had a BW <2500 g. One child had a PAX2 mutation requiring early renal transplantation and was thus excluded from further analysis. Even though glomerular filtration rate and blood pressure were normal in all other children, a significant urine albumin-to-creatinine ratio was found in three children and an increased urine beta-2-microglobulin concentration in an additional one, questioning the presence of an underlying silent reduction in nephron number.

Conclusions.

Despite the small number of patients, this pilot study highlights the potential risk of renal impairment in children born from dialysed mothers. Further studies are required but until then, careful monitoring of these children is important.

Keywords: children; dialysis; pregnancy; renal outcome

Journal Article.  3841 words. 

Subjects: Nephrology

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