Journal Article

Lymphoplasmacytic lymphoma causing light chain cast nephropathy

Nuria S. Pérez, Adriana Garcia-Herrera, Laura Rosiñol, Lily Palos, Evelyn Santiago, Gerard Espinosa, Manel Solé, Josep M. Campistol and Luis F. Quintana

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 1, pages 450-453
Published in print January 2012 | ISSN: 0931-0509
Published online January 2012 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfr730
Lymphoplasmacytic lymphoma causing light chain cast nephropathy

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Plasma cell dyscrasias are frequently associated with kidney disease through the production of monoclonal immunoglobulin but with a diverse set of pathologic renal patterns. While almost all patients with a renal biopsy showing a cast nephropathy have myeloma, kidney involvement associated with pathological immunoglobulin light chains and lymphoma is rare. To our knowledge, this is the first report of a cast nephropathy associated with lymphoplasmacytic lymphoma. We emphasize the relation between light chain deposition and renal dysfunction in this disease with production of light chains. A therapeutic approach that decreases light chain production appears to be warranted in these patients.

Keywords: acute renal failure; cast nephropathy; lymphoma; paraproteins

Journal Article.  1868 words.  Illustrated.

Subjects: Nephrology

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