Journal Article

The regulatory/cytotoxic infiltrating T cells in early renal surveillance biopsies predicts acute rejection and survival

Ying Xu, Juan Jin, Huiping Wang, Zhangfei Shou, Jianyong Wu, Fei Han, Qiang He, Jie Zhao, Yan Bi and Jianghua Chen

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 7, pages 2958-2965
Published in print July 2012 | ISSN: 0931-0509
Published online January 2012 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfr752
The regulatory/cytotoxic infiltrating T cells in early renal surveillance biopsies predicts acute rejection and survival

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Background

To analyze the immune phenotype of T-lymphocyte infiltrations in surveillance renal biopsies with stable renal function early post-transplantation (median time 40 days, range from 18 to 85 days).

Methods

One hundred and twenty-five surveillance biopsies with interstitial T-lymphocyte infiltration between non-atrophic tubules in the cortex (14 with subclinical rejection, 32 with borderline change and 79 with only interstitial T-lymphocyte infiltration but no obvious pathological abnormalities according to Banff criteria) were enrolled. All cases were classified into two groups: regulatory phenotype (RP) group, which was dominated by FOXP3-positive T lymphocytes in surveillance biopsies, and cytotoxic phenotype (CP) group, which was dominated by Granzyme B-positive T lymphocytes.

Results

The RP group includes 83.2% (104/125) cases, none of which developed acute rejection during nearly 5 years of follow-up. The CP group includes 16.8% (21/125) cases, all of which developed biopsy-proven acute rejection or clinical diagnostic acute rejection within 1 year after biopsy. Glomerular filtration rate and cumulative graft survival time were superior in the RP group than in the CP group (P < 0.001).

Conclusion

Analyzing the immunophenotype of graft-infiltrating T cells in renal surveillance biopsies during early post-transplantation could predict acute rejection and survival.

Keywords: acute rejection; immunophenotype; renal transplantation; surveillance biopsy

Journal Article.  4088 words.  Illustrated.

Subjects: Nephrology

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