Journal Article

Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia

Richard McCrory, Moyra Gray, Niall Leonard, John Smyth and Alastair Woodman

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 3, pages 1269-1271
Published in print March 2012 | ISSN: 0931-0509
Published online March 2012 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfs002
Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia

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BK virus nephropathy (BKVN) is a well-recognized complication of renal transplantation. Several cases of native kidney BKVN following other solid organ or bone marrow transplants have been reported. We describe a patient with chronic lymphocytic leukaemia who presented with deteriorating renal function with no history of solid organ or bone marrow transplantation. Renal biopsy demonstrated tubular injury characteristic of viral infection, confirmed as BK virus by immunohistochemistry and elevated serum BK viral titres. Treatment with leflunomide reduced serum viral titres and stabilized renal function. This is the first biopsy-proven case of native kidney BKVN in a patient with no previous transplantation history.

Keywords: BK virus nephropathy; chronic lymphocytic leukaemia; leflunomide

Journal Article.  1117 words.  Illustrated.

Subjects: Nephrology

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