Journal Article

The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus

Salvatore De Cosmo, Sabrina Prudente, Olga Lamacchia, Daniela Lucchesi, Hetal Shah, Christine Mendonca, Laura Pucci, Luana Mercuri, Ernest V. Gervino, Thomas H. Hauser, Diego Bailetti, Giuseppe Penno, Mauro Cignarelli, Alessandro Doria and Vincenzo Trischitta

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 12, pages 4411-4413
Published in print December 2012 | ISSN: 0931-0509
Published online May 2012 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfs148
The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus

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Background

We investigated whether the coronary artery disease (CAD) locus on chromosome 9p21 (as represented by single nucleotide polymorphism rs2383206) is associated with low estimated glomerular filtration rate (eGFR) or increased urinary albumin excretion in patients with Type 2 diabetes mellitus (T2DM).

Methods

Four samples, including a total of 3167 patients, were studied. The presence of low eGFR (<60 mL/min/1.73m2) was estimated from serum creatinine by means of the Modification of Diet in Renal Disease Study equation. Increased urinary albumin excretion was defined as an albumin–creatinine ratio (ACR) ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women.

Results

No association was found between rs2383206 and low eGFR or increased ACR in each sample as well as in a pooled analysis (overall odds ratio = 1.07, 95% confidence interval 0.94–1.22, P = 0.31 and overall odds ratio = 1.00, 95% confidence interval 0.90–1.12, P = 0.95, respectively). No interaction was observed between rs2383206 and poor glycemic control [HbA1c was above the median in the pooled sample (7.7%) in modulating eGFR or ACR (P for interaction = 0.42 and 0.90, respectively)].

Conclusion

Variability at the 9p21 CAD locus is unlikely to play a role in modulating susceptibility to kidney dysfunction in patients with T2DM.

Keywords: albuminuria; coronary artery disease; gene polymorphism; glomerular filtration rate

Journal Article.  1489 words. 

Subjects: Nephrology

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